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- W2377261566 abstract "Aim To study the effect of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside on expression of adhesion molecules P-selectin,E-selectin,ICAM-1,VCAM-1 and MCP-1 induced by H2O2 on human umbilical vein endothelial cells(HUVECs).Methods HUVECs were cultured in vitro.The experiment was divided into four groups: control group,H2O2 group,positive group,and TSG group.The expression of P-selectin,E-selectin,ICAM-1,VCAM-1 and MCP-1 mRNA and protein were respectively detected by reverse transcriptase polymerase chain reaction(RT-PCR) and enzyme-linked immunosorbent assay(ELISA).Results After endothelial cells treated with 200 μmol·L-1 H2O2 for 24 h,the expression of P-selectin,E-selectin,ICAM-1,VCAM-1 and MCP-1 mRNA and protein level was significant higher.After TSG pretreatment endothelial cells for 4h before treated with 200 μmol·L-1 H2O2,results showed that TSG could inhibit the expression of P-selectin,E-selectin,ICAM-1,VCAM-1 and MCP-1 mRNA and protein level induced by H2O2 on endothelial cells.Conclusion TSG can inhibit the expression of adhesion molecules induced by H2O2 on human umbilical vein endothelial cells and accordingly slow down atherosclerosis." @default.
- W2377261566 created "2016-06-24" @default.
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- W2377261566 date "2012-01-01" @default.
- W2377261566 modified "2023-09-24" @default.
- W2377261566 title "Effect of TSG on expression of adhesion molecule induced by H_2O_2 on vascular endothelial cell" @default.
- W2377261566 hasPublicationYear "2012" @default.
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