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- W2377263462 abstract "Objective This study was designed to investigate the relationship between-308bp polymorphism in tumor necrosis factor-α(TNFα) gene and +252bp in lymphotoxin-α(LTα)gene and the pathogenesis, clinical course and outcome of multiple myeloma(MM).Methods The single base change polymorphism in TNFα gene and LTα gene were analyzed among 32 chinese patients with MM and 72 normal controls by using PCR-restrictive fragment length polymorphism (RFLP).The clinical data were collected and survival analysis was performed. Results (1)The difference of distribution of genotypes,alleles of TNFα(-308), LTα(+252)and TNF/LT polymorphic extended haplotypes between the MM patients and control group were not statistically significant(P 0.05).(2)In patients group , no statistically significant association was found between the presence of a given TNF/LT haplotype status and clinical characters such as sex, age, clinical stags,myeloma burthen, hemoglobin, creatinine. (3)The estimated 2-year and 4-year overall survival rates in the groups of patients carrying high-risk and low-risk haplotypes were not statistically significant(P 0.05) using Kaplan-Meier method. In multivariate Cox regression models the TNF/LT haplotype status was not found to be risk factors for outcome(P 0.05). Conclusion These data suggest that genetic polymorphisms in the TNFα(-308),LTα(+252) are not crucial in the pathogenesis ,clinical course,outcome of MM patients." @default.
- W2377263462 created "2016-06-24" @default.
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- W2377263462 date "2005-01-01" @default.
- W2377263462 modified "2023-09-25" @default.
- W2377263462 title "Clinical Relationship between Tumor Necrosis Factor Genetic Polymorphisms and Multiple Myeloma" @default.
- W2377263462 hasPublicationYear "2005" @default.
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