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- W2377277253 abstract "Objective To investigate the effect of lycopene on growth of human gastric carcinoma cells in vitro.Methods The human gastric carcinoma SGC-7901 cells were treated with lycopene.IC_(50) of lycopene on SGC-7901 cells calculated by 3-(4,5-dimethylthiazole-2yl)-2,5 diphenyl tetrazoliumbromide(MTT) assay.The rate of growth suppression on SGC-7901 cells was evaluated by cell growth curve and clone formation.The effect of lycopene on DNA synthesis of human gastric carcinoma SGC-7901 cells was evaluated by()~3H-thymidine(()~3H-TdR) incorporation.Cell morphology was observed by inverted microcope.Results Lycopene had significantly inhibitory effect on growth of human gastric carcinoma SGC-7901 cells,IC_(50) of 24,48,72,96,120,148,172h were 1.0×10~(-4),9.2×10~(-5),2.6×10~(-5),4.8×10~(-5),3.5×10~(-5),4.3×10~(-5) and 3.1×10~(-5)?mol/L,respectively.Treated with 0.3×10~(-4),0.5×10~(-4)、10~(-4)?mol/L lycopene for 172?h,the rate of cells growth suppression was 64.75%,79.02%,87.13%,respectively.Treated with 0.3×10~(-4),0.5×10~(-4),10~(-4)?mol/L lycopene for 24?h the rate of cloning formation of SGC-7901 cells was(30.2±1.9)%,(22.0±2.1)%,(16.9±2.0)%,respectively.Treated with 0.3×10~(-4),0.5×10~(-4),10~(-4)?mol/L lycopene for 48?h,()~3H-TdR in corporation of human gastric carcinoma SGC-7901 cells were(3757.06±114.27),(3148.24±190.23),(2408.32±155.83)cpm,respectively,which showed significantly decreased(P0.01),as compared with that in negative control group which were(5470.25±217.16)cpm;light absorption(value A) of human gastric carcinoma SGC-7901 cells also showed significant decrease(P0.01),as compared with that in negative control group.The morphological changes of human gastric carcinoma SGC-7901 cells were observed after treated with 0.3×10~(-4),0.5×10~(-4),10~(4)?mol/L lycopene for 24?h,such as rounder,smaller,desquamation,sparse arrangement,vacuole of different size and etc.Conclusion Lycopene can significantly inhibit proliferation of human gastric carcinoma SGC-7901 cells in dose-response manner in vitro." @default.
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- W2377277253 date "2006-01-01" @default.
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- W2377277253 title "Effect of lycopene on growth of gastric carcinoma cells" @default.
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