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- W2377278001 abstract "Aim: To investigate ultrastructure manifestation of vertebral bodies after percutaneous vertebroplasty (PVP) in osteoporotic goats with three different filling materials:polymethylmethacrylate (PMMA), calcium phosphate cement (CPC) and rhBMP-2/CPC. Methods: The bilateral ovaries of the eight goats, 6 to 8 years old, were removed to set up the osteoporotic model. Two vertebral bodies (L_2~L_6) of each goat were selected at random, which were augmented with PMMA, CPC or rhBMP-2/CPC, respectively under fluoroscopic guidance and intravenous anaesthesia. The filling materials were different in two vertebras of each goat. Sixteen vertebral bodies from eight goats were observed under scan electron microscope after four months. Results: PVP was performed successfully in all the sixteen vertebral bodies,and the leakage of cement was found in 5 vertebras. Scan electron microscope results revealed that only few cells could be found at the surface of PMMA.The resorption of PMMA or the new bone formation could not be found. In contrast to PMMA, a seamless contact existed between CPC and bone trabecula, and more cells, new bone formation and resorption of CPC were observed. More osteoblasts and the formation of some mature bone trabeculaes could be found in vertebra filled with rhBMP-2/CPC. Conclusion: The results indicate that CPC and rhBMP-2/CPC are biocompatible and osteoconductive. What is more, the latter might be the best candidate material as a bone substitute in the treatment of osteoporosis with PVP." @default.
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- W2377278001 date "2007-01-01" @default.
- W2377278001 modified "2023-09-22" @default.
- W2377278001 title "Ultrastructure evaluation of vertebral bodies after percutaneous vertebroplasty with three different filling materials in goats" @default.
- W2377278001 hasPublicationYear "2007" @default.
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