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- W2377291274 abstract "Objective To study the protective effect of sarpogrelate hydrochloride, an inhibitor of serotonin 2A receptor antagonist, on renal disease in rats with diabetes mellitus.Methods Forty Spaque-Dawley rats were divided into three groups: normal controls group(NC), sarpogrelate hydrochloride-treated group(SH), and diabetic rats group (DM). Levels of blood nitric oxide,urine microalbumin and serum creatinine were mea-sured on the 12th week. The expression of type Ⅳ collagen and endothehal nitricoxide synthase (eNOS) in renal cortex were measured by immunohistochemistry. Changes of glomerulas were observed under light microscope and electron microscope.Results Compared with DM group, rats in the SH group had significantly lower urine microalbumin excretory rate (UAER) and renal weight/body weight ratio and increased levels of blood nitric oxide(both P0.01). Besides, the pathological changes in the SH group were greatly improved: foot process fusion was not evident, the infiltration membrane was basically intact, the mesangial region had no obvious widening, and the endothelial cells were not swollen. The glomerular area and glomerular volume in the SH group were significantly smaller than those of DM group (both P0.01); the serum NO concentration in the SH group was markedly increased (P0.05); and the expression of renal type Ⅳ collagen was significantly decreased (P0.01) and the expression of eNOS was significantly increased (P0.05).Conclusion Antagonist of 5-HT2A receptor sarpogrelate hydrochloride can ameliorate diabetic nephropathy, probably through reducing the expression of renal type Ⅳ collagen protein, up-regulating the expression of eNOS protein, thus improve the damages of diabetic nephropathy and delay its progression." @default.
- W2377291274 created "2016-06-24" @default.
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- W2377291274 date "2008-01-01" @default.
- W2377291274 modified "2023-09-23" @default.
- W2377291274 title "Effects of sarpogrelate hydrochloride on renal injury of diabetic rats" @default.
- W2377291274 hasPublicationYear "2008" @default.
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