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- W2377302575 abstract "Objective To study the of telomerase activity and detection mutatil P53 gene at eh resection margin of the bronehus and cancer tissues, and to prediet Lung cancer recurrence. Methods PCR- SSCP technique was used to (no cancer cells remained) the lungs in 60 patients with lung cancer and 10 patients with non-eaneemus pulmonary diseases. Results Of the 60 patients, 16 cases (27%) had telomerase activity and p53 gene mutation at the resection margin of bronchus and 30 cases (50%). Telomerase aetieity and the mutation rate of p53 gene in cancer tissue was 100% for small cell Lung cancer, 70% for squanous cell carcinoma. Mutation rate of telomerase of p53 gene Ⅱ, 25% (4/16) in stagel Ⅰ.During follow-uup (ranged from 3 months to 8 months), 10 patients (63%) with telomeras activity and mutant p53 gene at the resection margin had local recurrence. There was recurrence in patients without telomerase activity and mutant p53 gene at the resection margin.20 patients (67%) with mutant p53 gene and telomerase nagtive. Without telomerase activity and mutant p53 gene had local tecurrence (P0.05). Conclusion By testing telomerae activity and mutant of p53 gene at the resection margins of bronchus, we may predict local recurrence of lung cancer." @default.
- W2377302575 created "2016-06-24" @default.
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- W2377302575 date "2004-01-01" @default.
- W2377302575 modified "2023-09-25" @default.
- W2377302575 title "Expression of Telomerase Activity and Detection of Mutant p53 Gene at Resection Margin of the Bronchus to Human Lung Cancer Incisal" @default.
- W2377302575 hasPublicationYear "2004" @default.
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