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- W2377305422 abstract "【Objective】 Establish the precocious puberty model in female rats induced by excitatory amino acids receptor agonist. 【Methods】 Fifty 26-day-old female rats were randomly assigned to 5 groups,experimental groupⅠ(early phase of precocious puberty),the second experimental groupⅡ(metaphase of precocious puberty),control groupⅠ(normal prepuberty),control groupⅡ(early phase of normal puberty),control groupⅢ(metaphase of normal puberty).Study group received subcutaneous injection of N-methyl-DL-aspartate acid(NMA) twice a day until vaginal opening(VO) occurred and control groups received saline.The parameters of puberty were analyzed,which including index of ovary,index of uterus,incidence of corpora lutea,thickness of uterus and serum luteinizing hormone. 【Results】 The age of VO and first diestrus of experimental groups were earlier than the control groups.The parameters of puberty in experimental groups were different from control groupⅠ.The parameters of puberty in experimental groupⅠ were not different from control groupⅡ.The parameters of puberty in experimental groupⅡ were not different from control groupⅢ. 【Conclusions】 The precocious puberty model in female rats were successfully established by subcutaneous injection of NMA." @default.
- W2377305422 created "2016-06-24" @default.
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- W2377305422 date "2011-01-01" @default.
- W2377305422 modified "2023-09-26" @default.
- W2377305422 title "Establishment of the precocious puberty model in female rats induced by excitatory amino acids receptor agonist" @default.
- W2377305422 hasPublicationYear "2011" @default.
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