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- W2377308510 abstract "Objective To investigate the correlation between serum angiopoietin-2(Ang-2)levels and postoperative recurrence and prognosis in the patients with advanced gastric cancer Methods The preoperative and 1 month postoperative serum Ang-2 levels in 85 patients with radical gastrectomy for advanced gastric cancer were measured by ELISA technique.The serum Ang-2 levels in 30 normal controls were also measured.The postoperative prognosis was followed-up,and the serum Ang-2 levels in the patients with recurred gastric cancer and the patients without recurred gastric cancer were repeatly measured.The factors that affected the preoperative serum Ang-2 levels were analyzed.The relation between the serum Ang-2 levels and postoperative recurrence and prognosis in the patients with advanced gastric cancer was investigated.Results The serum Ang-2 levels in advanced gastric cancer group were significantly higher than those in the normal controls[(345.3±141.8)μg/L vs.(187.4±32.7)μg/L,P0.01]and were significantly dereased 1 month after the operation(P0.01).The serum Ang-2 levels in the postoperative recurred gastric cancer group were significantly higher than those in the 1 month postoperation group and no recurrence gastric cancer group[(288.7±97.8)μg/L vs.(210.5±63.4)μg/L,(231.1±68.2)μg/L,P0.01].Univariate analysis revealed that preoperative high serum Ang-2 levels were related with differentiated degree of the tumor tissue,Borrmann type,tumor size,lymph node metastasis ratio,depth of tumor invasion(P0.05),but not related with the histological type(P0.05).Multivariate logistic regression analysis revealed that differentiated degree of the tumor tissue,tumor size,lymph node metastasis,depth of tumor invasion were independent risk factors for the elevation of preoperative serum Ang-2 levels in the advanced gastric cancer.Elevated preoperative serum Ang-2 levels negatively affected the postoperative survival rate and recurrence rate.Conclusions Preoperative elevated serum Ang-2 levels is related with some important pathologic features in patients with advanced gastric cancer,and may be an important prognostic factor.Postoperative serum Ang-2 levels change is useful for monitoring of recurrence of advanced gastric cancer." @default.
- W2377308510 created "2016-06-24" @default.
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- W2377308510 date "2012-01-01" @default.
- W2377308510 modified "2023-09-24" @default.
- W2377308510 title "Correlation between serum angiopoietin-2 levels and postoperative recurrence and prognosis in patients with advanced gastric cancer" @default.
- W2377308510 hasPublicationYear "2012" @default.
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