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- W2377328964 abstract "Objective:To study the adjustment effects of LaCL3 on lipid-hyperoxidation and vascular endothelium function in hyperlipidemia model rats.Methods:Fifty SD rats were randomly equally divided into 5 groups:control group,hyperlipidemia group,low dose of LaCL3 group (0.1 mg/kg),middle dose of LaCL3 group (2 mg/kg) and high dose of LaCL3 group (40mg/kg).Rats were fed with high fat diet except control group and the intervention tests were carried out meanwhile.After 12 weeks,blood lipid profile,the level of malondialdehyde (MDA),nitric oxide (NO),total anti-oxidant capability(T-AOC),ET-1 and Superoxide dismutase (SOD) activities were assessed.Results:The level of serum total cholesterol (TC),triglyceride (TG),low density lipoprotein (LDL-C),MDA and ET-1 of hyperlipidemia rats were all higher than those in control group.HDL-C,NO,T-AOC level and SOD activities were lower than those in control group(P0.05~0.01).Compared with hyperlipidemia group,Low dose of LaCL3 increased NO,T-AOC level and SOD activities,conversely it decreased the level of MDA and ET-1 in plasma(P0.05~0.01).Conclusion:Low dose of LaCL3 enhanced the antioxidation,inhibited the lipid peroxidation and improved the vascular endothelium function." @default.
- W2377328964 created "2016-06-24" @default.
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- W2377328964 date "2009-01-01" @default.
- W2377328964 modified "2023-09-22" @default.
- W2377328964 title "Effects of LaCl_3 on lipid-hyperoxidation and vascular endothelium function in hyperlipemia model rats" @default.
- W2377328964 hasPublicationYear "2009" @default.
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