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- W2377334359 abstract "Objective:To study the antitumor effects of different solvent extracts from Salicornia bigelovii Torr.and explore its mechanism.Methods:Using ultrasound-assisted extraction of the crude extract from Salicornia bigelovii Torr.with the N-hexane,ethyl acetate,N-butyl alcohol,methanol and water.MTT assay was used to evaluate the inhibiting effects of crude extracts on the proliferation of the cancer cells.Flow cytometry was applied to detect the Hela cells cycle with incubation of ethyl acetate extract.Results:The inhibitory effects of N-hexane,ethyl acetate and n-butyl alcohol extracts on in vitro carcinomata were significant.The IC50 of ethyl acetate extract on Hela cells was 17.6 μg/mL.It could inhibit the proliferation of Hela cells during G0/G1 period and significantly decreased the cell ratio G2/M of stage.Conclusion:N-hexane,ethyl acetate and n-butyl alcohol extracts showed a good antitumor activity.The ethyl acetate extract could block the cell cycle and induce its apoptosis.This mechanism is needed further research." @default.
- W2377334359 created "2016-06-24" @default.
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- W2377334359 date "2014-01-01" @default.
- W2377334359 modified "2023-10-03" @default.
- W2377334359 title "Antitumor effects and preliminary mechanism of crude extracts from Salicornia bigelovii Torr" @default.
- W2377334359 hasPublicationYear "2014" @default.
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