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- W2377348520 abstract "Objective:To improve the understanding of splenic marginal zone lymphoma(SMZL) and the level of diagnosis and therapy. Method:We report a case of a 75-year-old man with SMZL. The histopathological characteristics of cells in peripheral blood, bone marrow and spleen were studied with light microscopy, phase contrast microscopy, transmission electron microscopy, immunohistochemical method, RHG chromosome banding technique and PCR for detecting the IgH gene rearrangement. Result:The neoplastic cells of this patient were positive for CD2I) ,CD13 and bcl-2. Histologically,the spleen showed marked nodular expansion of white pulp with frequent merging and coalescence. In these regions, the marginal and mantle zones were replaced by neoplastic cells completely. There were no abnormal karyotype in bone marrow cells. The monoclonal pattern of IgH gene rearrangement was only found in spleen. Abnormal gymphocytic cells were not found in bone marrow and peripherel blood. Conclusion:When patient has progressive splenomegaly without superficial lymph node enlargement, SMZL should be considered. Monoclonal IgH gene rearrangement is an important evidence for the diagnosis. Follicular lympho-ma and mantle cell lymphoma need to be identified. Splenectomy appears to obtain a good clinical response." @default.
- W2377348520 created "2016-06-24" @default.
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- W2377348520 date "2003-01-01" @default.
- W2377348520 modified "2023-09-24" @default.
- W2377348520 title "The clinical features and histopathological characteristics of splenic marginal zone B cell lymphoma : a case report" @default.
- W2377348520 hasPublicationYear "2003" @default.
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