Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377355943> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2377355943 abstract "OBJECTIVE A HPLC method was developed to determine directly propranolol glucuronide in urine of healthy volunteers and evaluate the stereoselectivity of racemic propranolol glucuronidation metabolism. METHODS The standard for this direct assay was prepared by incubation of liver microsomes with R -(+)-propranolol. The R -(+)-propranolol glucuronide [ R -(+)-PG] obtained was purified and concentrated with solid-phase extraction. The stock concentration was measured, after enzymatic hydrolysis with β-glucuronidase,by an indirect method. The concentrations of R -(+) and S -(-)-propranolol glucuronide [ S - (-) PG] in urine were determined and their pharmacokinetic parameters were calculated. RESULTS The main pharmacokinetic parameters were as follow: K were (0.283?3±0.058) and(0.194?6±0.040)h -1 , t max were (1.75±0.33) and (2.21±0.45)h, X u were (2.952±0.615) and (5.648±0.977)μmol for R -(+)-PG and S -(-)PG respectively. CONCLUSION The glucuronidation of racemic propranolol in human has stereoselectivity." @default.
- W2377355943 created "2016-06-24" @default.
- W2377355943 creator A5075033726 @default.
- W2377355943 date "2004-01-01" @default.
- W2377355943 modified "2023-09-27" @default.
- W2377355943 title "Study on the stereoselectivity of racemic propranolol glucuronidation metabolism" @default.
- W2377355943 hasPublicationYear "2004" @default.
- W2377355943 type Work @default.
- W2377355943 sameAs 2377355943 @default.
- W2377355943 citedByCount "0" @default.
- W2377355943 crossrefType "journal-article" @default.
- W2377355943 hasAuthorship W2377355943A5075033726 @default.
- W2377355943 hasConcept C112705442 @default.
- W2377355943 hasConcept C134018914 @default.
- W2377355943 hasConcept C161790260 @default.
- W2377355943 hasConcept C179998833 @default.
- W2377355943 hasConcept C181199279 @default.
- W2377355943 hasConcept C181647583 @default.
- W2377355943 hasConcept C185592680 @default.
- W2377355943 hasConcept C2778151854 @default.
- W2377355943 hasConcept C2779186261 @default.
- W2377355943 hasConcept C2779907587 @default.
- W2377355943 hasConcept C2780026642 @default.
- W2377355943 hasConcept C43617362 @default.
- W2377355943 hasConcept C55493867 @default.
- W2377355943 hasConcept C62231903 @default.
- W2377355943 hasConcept C71924100 @default.
- W2377355943 hasConcept C87644729 @default.
- W2377355943 hasConcept C94412978 @default.
- W2377355943 hasConcept C98274493 @default.
- W2377355943 hasConceptScore W2377355943C112705442 @default.
- W2377355943 hasConceptScore W2377355943C134018914 @default.
- W2377355943 hasConceptScore W2377355943C161790260 @default.
- W2377355943 hasConceptScore W2377355943C179998833 @default.
- W2377355943 hasConceptScore W2377355943C181199279 @default.
- W2377355943 hasConceptScore W2377355943C181647583 @default.
- W2377355943 hasConceptScore W2377355943C185592680 @default.
- W2377355943 hasConceptScore W2377355943C2778151854 @default.
- W2377355943 hasConceptScore W2377355943C2779186261 @default.
- W2377355943 hasConceptScore W2377355943C2779907587 @default.
- W2377355943 hasConceptScore W2377355943C2780026642 @default.
- W2377355943 hasConceptScore W2377355943C43617362 @default.
- W2377355943 hasConceptScore W2377355943C55493867 @default.
- W2377355943 hasConceptScore W2377355943C62231903 @default.
- W2377355943 hasConceptScore W2377355943C71924100 @default.
- W2377355943 hasConceptScore W2377355943C87644729 @default.
- W2377355943 hasConceptScore W2377355943C94412978 @default.
- W2377355943 hasConceptScore W2377355943C98274493 @default.
- W2377355943 hasLocation W23773559431 @default.
- W2377355943 hasOpenAccess W2377355943 @default.
- W2377355943 hasPrimaryLocation W23773559431 @default.
- W2377355943 hasRelatedWork W1029505450 @default.
- W2377355943 hasRelatedWork W1989910524 @default.
- W2377355943 hasRelatedWork W1997616642 @default.
- W2377355943 hasRelatedWork W2002871222 @default.
- W2377355943 hasRelatedWork W2034015482 @default.
- W2377355943 hasRelatedWork W2067256490 @default.
- W2377355943 hasRelatedWork W2075966865 @default.
- W2377355943 hasRelatedWork W2077570708 @default.
- W2377355943 hasRelatedWork W2080050897 @default.
- W2377355943 hasRelatedWork W2338709647 @default.
- W2377355943 hasRelatedWork W2339511975 @default.
- W2377355943 hasRelatedWork W2352203038 @default.
- W2377355943 hasRelatedWork W2365584449 @default.
- W2377355943 hasRelatedWork W2397219617 @default.
- W2377355943 hasRelatedWork W2398813985 @default.
- W2377355943 hasRelatedWork W2403381243 @default.
- W2377355943 hasRelatedWork W2419356766 @default.
- W2377355943 hasRelatedWork W2471169735 @default.
- W2377355943 hasRelatedWork W2474753434 @default.
- W2377355943 hasRelatedWork W2785637045 @default.
- W2377355943 isParatext "false" @default.
- W2377355943 isRetracted "false" @default.
- W2377355943 magId "2377355943" @default.
- W2377355943 workType "article" @default.