Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377366927> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2377366927 startingPage "538" @default.
- W2377366927 abstract "BACKGROUND & OBJECTIVE Estrogen receptor-related receptor alpha (ERRalpha), a member of the subfamily of orphan nuclear receptors, could compete with estrogen receptor alpha (ERalpha) to bind the same target genes and interfere in ER signal pathway. Therefore, it might be associated to the tumorigenesis of endometrial carcinoma. This study was to explore the regulatory effect of 17beta-estradiol (17beta-E(2)) on ERRalpha expression, and to elucidate the relationship between ERRalpha and ER signal pathway in endometrial carcinoma cell lines. METHODS ERalpha-positive cell line Ishikawa and ERalpha-negative cell line HEC-IA were treated with different concentrations of 17beta-E(2) (1x10(-10) mol/L, 1x10(-8) mol/L, and 1x10(-6) mol/L) for 24 h and 48 h, respectively. The levels of ERRalpha mRNA and protein were examined by reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. 17beta-E(2) (1x10(-8) mol/L) and complete ER inhibitor ICI182,780 (1x10(-6) mol/L) were given concomitantly to observe the change of ERRalpha expression. RESULTS The levels of ERRalpha mRNA and protein in Ishikawa cells were down-regulated after stimulated for 24 h and 48 h by different concentrations of 17beta-E(2). The maximal effect was observed at the concentration of 1x10(-8) mol/L. When 17beta-E(2) and ICI182,780 were given simultaneously to Ishikawa cells, this down-regulation was blocked. However, the level of ERRalpha mRNA, not protein, in HEC-IA cells was up-regulated after stimulated by different concentrations of 17beta-E(2) for 24 h. After stimulated by 17beta-E(2) for 48 h, the level of ERRalpha protein was up-regulated, which could not be blocked by ICI182,780. CONCLUSIONS 17beta-E(2) can down-regulate the expression of ERRalpha in Ishikawa cells, which is mediated by ERalpha. 17beta-E(2) can up-regulate the expression of ERRalpha in HEC-IA cells, but this regulation cannot be blocked by ICI182,780." @default.
- W2377366927 created "2016-06-24" @default.
- W2377366927 creator A5001180498 @default.
- W2377366927 creator A5003061709 @default.
- W2377366927 creator A5028449710 @default.
- W2377366927 creator A5049396596 @default.
- W2377366927 creator A5056394671 @default.
- W2377366927 creator A5067578751 @default.
- W2377366927 date "2006-05-01" @default.
- W2377366927 modified "2023-09-27" @default.
- W2377366927 title "[Regulatory effect of 17beta-estradiol on expression of orphan nuclear receptor ERRalpha in endometrial carcinoma cell lines]." @default.
- W2377366927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16687070" @default.
- W2377366927 hasPublicationYear "2006" @default.
- W2377366927 type Work @default.
- W2377366927 sameAs 2377366927 @default.
- W2377366927 citedByCount "0" @default.
- W2377366927 crossrefType "journal-article" @default.
- W2377366927 hasAuthorship W2377366927A5001180498 @default.
- W2377366927 hasAuthorship W2377366927A5003061709 @default.
- W2377366927 hasAuthorship W2377366927A5028449710 @default.
- W2377366927 hasAuthorship W2377366927A5049396596 @default.
- W2377366927 hasAuthorship W2377366927A5056394671 @default.
- W2377366927 hasAuthorship W2377366927A5067578751 @default.
- W2377366927 hasConcept C104317684 @default.
- W2377366927 hasConcept C105580179 @default.
- W2377366927 hasConcept C121608353 @default.
- W2377366927 hasConcept C126322002 @default.
- W2377366927 hasConcept C127561419 @default.
- W2377366927 hasConcept C134018914 @default.
- W2377366927 hasConcept C153911025 @default.
- W2377366927 hasConcept C170493617 @default.
- W2377366927 hasConcept C172313692 @default.
- W2377366927 hasConcept C185592680 @default.
- W2377366927 hasConcept C201729690 @default.
- W2377366927 hasConcept C2776415932 @default.
- W2377366927 hasConcept C2777164284 @default.
- W2377366927 hasConcept C502942594 @default.
- W2377366927 hasConcept C530470458 @default.
- W2377366927 hasConcept C54355233 @default.
- W2377366927 hasConcept C55493867 @default.
- W2377366927 hasConcept C63932345 @default.
- W2377366927 hasConcept C71924100 @default.
- W2377366927 hasConcept C81885089 @default.
- W2377366927 hasConcept C84606932 @default.
- W2377366927 hasConcept C86339819 @default.
- W2377366927 hasConcept C86803240 @default.
- W2377366927 hasConceptScore W2377366927C104317684 @default.
- W2377366927 hasConceptScore W2377366927C105580179 @default.
- W2377366927 hasConceptScore W2377366927C121608353 @default.
- W2377366927 hasConceptScore W2377366927C126322002 @default.
- W2377366927 hasConceptScore W2377366927C127561419 @default.
- W2377366927 hasConceptScore W2377366927C134018914 @default.
- W2377366927 hasConceptScore W2377366927C153911025 @default.
- W2377366927 hasConceptScore W2377366927C170493617 @default.
- W2377366927 hasConceptScore W2377366927C172313692 @default.
- W2377366927 hasConceptScore W2377366927C185592680 @default.
- W2377366927 hasConceptScore W2377366927C201729690 @default.
- W2377366927 hasConceptScore W2377366927C2776415932 @default.
- W2377366927 hasConceptScore W2377366927C2777164284 @default.
- W2377366927 hasConceptScore W2377366927C502942594 @default.
- W2377366927 hasConceptScore W2377366927C530470458 @default.
- W2377366927 hasConceptScore W2377366927C54355233 @default.
- W2377366927 hasConceptScore W2377366927C55493867 @default.
- W2377366927 hasConceptScore W2377366927C63932345 @default.
- W2377366927 hasConceptScore W2377366927C71924100 @default.
- W2377366927 hasConceptScore W2377366927C81885089 @default.
- W2377366927 hasConceptScore W2377366927C84606932 @default.
- W2377366927 hasConceptScore W2377366927C86339819 @default.
- W2377366927 hasConceptScore W2377366927C86803240 @default.
- W2377366927 hasIssue "5" @default.
- W2377366927 hasLocation W23773669271 @default.
- W2377366927 hasLocation W23773669272 @default.
- W2377366927 hasOpenAccess W2377366927 @default.
- W2377366927 hasPrimaryLocation W23773669271 @default.
- W2377366927 hasRelatedWork W1980170175 @default.
- W2377366927 hasRelatedWork W1980397832 @default.
- W2377366927 hasRelatedWork W1990303871 @default.
- W2377366927 hasRelatedWork W2011881476 @default.
- W2377366927 hasRelatedWork W2014333417 @default.
- W2377366927 hasRelatedWork W2023298703 @default.
- W2377366927 hasRelatedWork W2029211334 @default.
- W2377366927 hasRelatedWork W2032095724 @default.
- W2377366927 hasRelatedWork W2033497799 @default.
- W2377366927 hasRelatedWork W2055409098 @default.
- W2377366927 hasRelatedWork W2060569928 @default.
- W2377366927 hasRelatedWork W2075553098 @default.
- W2377366927 hasRelatedWork W2094470848 @default.
- W2377366927 hasRelatedWork W2101252730 @default.
- W2377366927 hasRelatedWork W2136432553 @default.
- W2377366927 hasRelatedWork W2137681063 @default.
- W2377366927 hasRelatedWork W2145263125 @default.
- W2377366927 hasRelatedWork W2352279451 @default.
- W2377366927 hasRelatedWork W2393512243 @default.
- W2377366927 hasRelatedWork W2787013832 @default.
- W2377366927 hasVolume "25" @default.
- W2377366927 isParatext "false" @default.
- W2377366927 isRetracted "false" @default.
- W2377366927 magId "2377366927" @default.
- W2377366927 workType "article" @default.