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- W2377366947 abstract "AIM: Vaticanol(B,C and G),α-viniferin and hopeaphenol are resveratrol oligomers,which are documented to possess antitumor,antioxidative activities,and chemoprotective effects attributed to their anti-inflammatory activities.The present study was aimed at evaluating their effects on the release of histamine,tumor necrosis factor-α (TNF-α) and leukotrienes (LTs) from bone marrow-derived mast cells (BMMC) in vitro.Meanwhile,activation of extracellular signal-regulated kinases (ERK) was also investigated.METHOD: BMMC were prepared by isolating bone marrow cells from intact femurs(Balb/c mice) and culturing them for 4-5 weeks in RPMI-1640 medium,supplemented with 10% FCSand IL-3 (10 ng/ml).BMMC were sensitized with anti-DNP IgE and stimulated with DNP-BSA (30 ng/ml) to trigger release reaction.In the nonimmunological stimulation experiments,BMMC were directly stimulated with calcium ionophore A23187 (3.0 μmol/L).RESULT:All compounds examined showed inhibitory effects on mediator release from BMMC to a certain extent.In the release reaction mediated by IgE,both TNF-α and LTs were significantly reduced by above compounds in a concentration-dependent manner.Vaticanol B and C inhibited IgE-mediated histamine release at a concentration of 100 μmol/L.A23187-mediated histamine release was potently inhibited by vaticanol (B,C and G) and hopeaphenol,but not by α-viniferin.Most of the tested compounds substantially reduced TNF-α and LTs production mediated by IgE or A23187,but vaticanol C and G did not exhibit effective inhibition of A23187-mediated LTs release.IgE-mediated activation of ERK was strongly inhibited by α-viniferin and vativanol C.Incubated with above compounds for 48 hours,cell viability of BMMC was not influenced.CONCLUSION:Vaticanol (B,C and G),α-viniferin,and hopeaphenol are potent inhibitors of inflammatory mediator release from mast cells and without significant influence on the cell viability of BMMC." @default.
- W2377366947 created "2016-06-24" @default.
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- W2377366947 date "2004-01-01" @default.
- W2377366947 modified "2023-09-26" @default.
- W2377366947 title "Vaticanol (B,C and G),α-Viniferin,and Hopeaphenol Inhibit Mediator Release from Bone Marrow-Derived Mouse Mast Cells in vitro" @default.
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