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- W2377371878 abstract "Objective To observe the effect and mechanism of DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine(5-aza) on cell cycle change of rat bone marrow cells(BMC) induced by benzene.Methods BMC were randomly divided into three groups: control group,benzene-treated group which was exposed to 10 mmol /L benzene for 24 h,benzene + 5-aza group which was exposed to 10 mmol /L benzene for 24 h and then treated with 10 μmol /L 5-aza for 72 h.Cell cycle was monitored by flow cytometry.Cyclin D1 and p27 mRNA expression were determined by real-time PCR,and Cyclin D1 and p27 protein expression were detected by western blot.Results The S phase ratio in benzene-treated group significantly increased 42.5% compared to the control,G1 phase ratio decreased 31.5%(P 0.01),and accompanied with the significant increase in the expressions of Cyclin D1 mRNA and protein and the significant decrease in the expressions of p27 mRNA and protein(P 0.01).The G1 phase ratio in benzene + 5-aza group increased 52.7%(P 0.01) compared to benzene-treated group,S phase ratio decreased 56.2%(P 0.01),and the expressions of Cyclin D1,p27 mRNA and protein were both significantly reversed.Conclusion 5-aza can affect cell cycle change of benzene-treated cell through regulating the expressions of Cyclin D1,p27 mRNA and protein." @default.
- W2377371878 created "2016-06-24" @default.
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- W2377371878 date "2011-01-01" @default.
- W2377371878 modified "2023-09-28" @default.
- W2377371878 title "Effect and mechanism of 5-aza-2′-deoxycytidine on cell cycle change of rat bone marrow cells induced by benzene in vitro" @default.
- W2377371878 hasPublicationYear "2011" @default.
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