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- W2377378947 abstract "Objective To investigate the effects of curcumin combined with Rapamycin on cell proliferation,autophagy,and apoptosis in Pten-CaP8 cells of castration refractory prostate cancer(CRPC).Methods Cells were treated by different concentrations of curcumin with or without Rapamycin for 24 h.Cell proliferation was analyzed by MTT.Cell morphology was detected by light microscopy.Expression of cell protein was evaluated by Western blotting.Results Curcumin combined with Rapamycin could significantly inhibit the Pten-CaP8 cell proliferation(P0.05),up-regulate LC3-II/LC3-I,induce PARP cleavage,and down-regulate the protein expression levels of p-AKT(S473),p-S6(S240/244),AR(N-20),and Cyclin D1.Treated cells became short and changed to cytoplasmic vacuoles.Conclusion Through the induction of autophagy and apoptosis simultaneously,curcumin combined with Rapamycin exerts synergistic antitumor activities correlated to the inhibition of PI3K/Akt/mTOR signaling pathways." @default.
- W2377378947 created "2016-06-24" @default.
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- W2377378947 date "2012-01-01" @default.
- W2377378947 modified "2023-09-24" @default.
- W2377378947 title "Autophagy and apoptosis of Pten-CaP8 cells in castration refractory prostate cancer induced by curcumin combined with Rapamycin" @default.
- W2377378947 hasPublicationYear "2012" @default.
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