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- W2377392009 abstract "Objective To study the relationships of serum osteocalcin (sOC), serum cross-linked N-telopeptide of collagen type I (sNTX),serum bone alkaline phosphatase (BAP) with bone mineral density (BMD) in normal men aged 20～80 years old. Method sOC,sNTX and BAP were measured using ELISA, areal BMD at anteroposterior (AP) lumbar spine,supine lateral lumbar spine,and hip using DXA (QDR 4500 A), in 309 normal males. Results (1) BMD values at all sites were negatively correlated with BAP(r=-0.087～-0.190, P0.05); BMD value at anteroposterior (AP) lumbar spine was negatively correlated with sOC and sNTX (r=-0.007,-0.100, P0.05);(2) After adjusted age,weight and smoking, BMD values at all sites but supine lateral lumbar spine were yet negatively correlated with BAP(r=-0.105～-0.191, P0.05); BMD value at anteroposterior (AP) lumbar spine was negatively correlated with sNTX (r=-0.164,P0.05); no correlations were found between sOC values and BMD values at all sites.(3) Men over 50 were stratified by BMD, BAP value of men with OP higher than the other groups.(4) Multiply regression analysis was made,taking BMD values at all sites as dependent variables,age,BMI,BAP,sOC,sNTX,smoking age and quantity as independent variables. Age and BMI enter all regression equation of BMD in all sites;smoking enters the regression equation of BMD at anteroposterior (AP) lumbar spine and hip region and Ward's region; BAP enters the ones of BMD, which explains the percentages of variance of BMD 16.5%,18.0%,13.4 and 10.8% respectively at anteroposterior (AP) lumbar s pine, supine lateral lumbar spine,total hip, femoral neck and Ward's region. sNTX enters the one of BMD,which accounts for the percentages of variance of BMD 15.7% at anteroposterior (AP) lumbar spine (all P0.05). Conclusion (1) BMD values at all sites are negatively correlated with BAP; After adjusted age,weight and smoking, BMD values at all sites but supine lateral lumbar spine are negatively correlated with BAP. BMD value at anteroposterior (AP) lumbar spine is negatively correlated with sNTX among men over 50. (2) Among men over 50, BAP values of those with OP are higher than those with bone loss and the control group, sNTX values of those with OP higher than the control group,suggesting correlation between higher bone metabolism level and bone loss. (3) Age,BMI and smoking are the independent risk factors of BMD values at all sites in males." @default.
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- W2377392009 date "2007-01-01" @default.
- W2377392009 modified "2023-09-29" @default.
- W2377392009 title "Relationships between serum osteocalcin (sOC),serum cross-linked N-telopeptide of collagen type I(sNTX),serum bone alkaline phosphatase (BAP) and bone mineral density (BMD) in normal men aged 20～80 years old" @default.
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