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- W2377403184 abstract "ObjectiveTo investigate the role of interleukin 12 (IL 12) administered intratracheally in different phases on the antigen induced airway reactions Methods Interleukin 12 was administered in sensitization phase and challenge phase in an asthma model established in C57BL/6 mice by OVA immunization respectively, the cellular composition of bronchoal veolar lavage fluid, the cytokines secreted by lung lymphoid cells and serum IgE level were analyzed Results ① In allergic sensitization, IL 12 strikingly inhibited the IL 5 production from lung lymphoid cells, and also inhibited the total OVA specific IgE levels in sera, and decreased the BAL eosinophilic infiltration following antigen challenge ② During antigen challenge phase, IL 12 inhibited the recruitment of eosinophils in the airway, down regulated the IL 5, and up regulated interferon gamma (IFN γ), but had no effect on IgE levels ③When administered in both sensitization phase and challenge phase, IL 12 down regulated IL 4 and IL 5 production from lung lymphoid cells and IgE levels in serum, inhibited the eosinophilic infiltration and increased IFN γ expression Conclusions IL 12 administered intratracheally has significant effects of immunomodulation effects on allergic lung inflammation that provides a new approach to the use of IL 12 in treatment of asthma" @default.
- W2377403184 created "2016-06-24" @default.
- W2377403184 creator A5029786470 @default.
- W2377403184 date "2001-01-01" @default.
- W2377403184 modified "2023-09-25" @default.
- W2377403184 title "Inhibition of antigen-induced airway allergic inflammation in mice by intratracheal administration of recombinant IL 12" @default.
- W2377403184 hasPublicationYear "2001" @default.
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