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- W2377407893 abstract "AIM: To investigatethe the relationship between the expression of βⅢ-tubulin protein and chemoresistance to taxane in non-small cell lung cancer(NSCLC).METHODS: Seventy-five patients with stage Ⅳ NSCLC treated with taxane were enrolled in this study and their clinical data were analyzed retrospectively.The expression of βⅢ-tubulin protein in tumor samples was detected by the immunohistochemical methods.The data of therapeutical effect and survival time were collected and analyzed.RESULTS: The βⅢ-tubulin positive staining rate(≥50% of stained cells) accounted for 58.7%(44/75).There was no correlation between βⅢ-tubulin positive expression and age,gender,and pathological type.The response rate(CR+PR) was 34.7%.Patients with βⅢ-tubulin overexpression displayed less response rate and more progression rate to taxane(response rate 25.0%,PD 25.0% in patients with ≥50% of stained cells vs response rate 48.89%,PD 6.5% in patients with 50%,P=0.036 and P=0.037,respectively).Overexpression of βⅢ-tubulin protein expression was correlated with shorter median overall survival(12 months) and progression-free survival(8 months),While a low level of βⅢ-tubulin protein expression was correlated with longer median overall survival(15 months) and progression-free survival(11 months),P=0.018.CONCLUSION: Overexpression of βⅢ-tubulin in tumor cells is associated with resistance to taxane and a poor prognosis in patients with NSCLC receiving taxane-based chemotherapy." @default.
- W2377407893 created "2016-06-24" @default.
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- W2377407893 date "2008-01-01" @default.
- W2377407893 modified "2023-09-23" @default.
- W2377407893 title "Relationship between expression of β_III-tubulin and drug resistance to taxane in stage IV non-small cell lung cancer" @default.
- W2377407893 hasPublicationYear "2008" @default.
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