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- W2377408085 abstract "Objective To shed light on the question that if the tension changes of pulmonary resistant arteries (PRA, small arteries with the diameter of 0.3～0.6mm) caused by radiographic contrast media are mediated by endothelin and EDRF.Materials and Methods PRAs were dissected off from Wistar rat lungs, mounted as ring preparations and bathed in normal saline, which was gassed with the mixture of 95% O 2 and 5% CO 2. A passive transmural pressure of 17.5mmHg was given, the tensions of the rings were recorded automatically through a force transducer. The following experiments were carried out: (1) PRAs were exposed to 40mgI/ml Diatrizoate (or its mannitol osmolar control solution) for 20min, the vasoconstriction was recorded. After washing the testing solution off with normal saline, 10 -5 mol/L SB209670 was added, then 40mgI/ml Diatrizoate (or its mannitol control) was added again, after 20min the vasoconstriction was recorded. (2) PRAs were preconstricted with 10 -4 mol/L prostaglandin F 2α , 80mgI/ml Ioxaglate was added and the vasorelaxation was recorded, after washing off the testing solution, 10 -4 mol/L LNAME and 7.5×10 -6 mol/L prostaglandin F 2α , were used to create experimental group PRA preconstricition (comparable to those caused by 10 -4 mol/L prostaglandin F 2α ), 80mgI/ml Ioxaglate was added and the vasorelaxation was recorded. For the control group, the second preconstriction was induced by 10 -4 mol/L prostaglandin F 2α .Results (1) Exposure of PRA to 40mgI/ml Diatrizoate and its mannitol control for 20min caused 41.9%± 2.3% and 26.9%± 2.6% KEmax (maximum constriction caused by potassium ion), respectively. After PRA pretreated with SB209670, 42.1%± 2.7% and 27.5%± 2.9% KEmax constriction were produced, respectively. In both diatrizoate and mannitol solution groups no significant difference was found between the consecutive vasoconstriction before and after the treatment of SB209670. (2) In control group, the first and second testing 80mgI/ml Ioxaglate caused 33.4%± 4.2% and 36.7%± 3.9% relaxation, respectively (expressed in percentage of preconstriction), no significant difference was found. In experimental group the first and second testing 80mgI/ml Ioxaglate caused 38.2%± 1.6% and 43.6%± 2.2% relaxation, respectively, no significant difference was found.Conclusion This study indicates that endothelin is not the dominant factor mediating isolated PRA constriction induced by Diatrizoate or high osmolar solution, EDRF is not the dominant factor mediating ioxaglateinduced isolated PRA vasorelaxation." @default.
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- W2377408085 date "2000-01-01" @default.
- W2377408085 modified "2023-09-24" @default.
- W2377408085 title "Factors Mediating Tension Changes of Pulmonary Resistant Arteries Caused by Radiographic Contrast MediaA Study on Endothelin and EDRF" @default.
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