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- W2377416182 abstract "Objective To study the significance of intraglomerular deposition of fibrinogen(Fg) in IgA nephropathy. Methods 103 patients were divided into two groups according to immunofluorescence results of renal biopsy: group A,without Fg deposition in the glomeruli;group B with Fg deposition in the gromeruli.Their clinical data(age,gender,blood pressure,plasma Fg,serum creatinine,serum urea,urine IgG,urine microalbumin,24 hour urine protein) and pathological data related to prognosis of IgA nephropathy were reviewed retrospectively. Results Between the two groups,higher levels of plasma Fg and significantly higher serum urea,urine IgG,urine microalbumin,24 hour urine protein were noted in group B(P0.01),the incidence of Ig only depositing in the mesangial area was significantly lower(P0.01),the incidence of IgA combined with IgG and IgM depositing in the glomeruli and Ig depositing in both mesangial area and capillary area were significantly higher(P0.01);in the major risk factors on prognosis of IgA nephropathy,in group B there was a higher incidence of large proteinuria(1.0g/24h) and renal interstitial fibrosis and significantly higher(P0.01) incidence of renal insufficiency(115umol/L),glomerulosclerosis,renal arteriolar lesion. Conclusion Fg depositing in the glomeruli played an important role in the clinical and pathological course of IgA nephropathy." @default.
- W2377416182 created "2016-06-24" @default.
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- W2377416182 date "2008-01-01" @default.
- W2377416182 modified "2023-09-25" @default.
- W2377416182 title "Significance of intraglomerular deposition of Fibrinogen in IgA nephropathy." @default.
- W2377416182 hasPublicationYear "2008" @default.
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