Matches in SemOpenAlex for { <https://semopenalex.org/work/W2377433269> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2377433269 endingPage "201" @default.
- W2377433269 startingPage "200" @default.
- W2377433269 abstract "Objective To get an improved synthesis of nevirapine.Methods Compound 3 was got via the formation of the amide from 2-chloro-3-amino-4-methyl pyridine and 2-chloronicotinoyl chloride,and then nevirapine was acquired by the aminolysis of 3 with cyclopropylamine in an autoclave,followed by the intramolecular nucleophilic substitution.Results The target compound was synthesized via 3 steps with a total yield of 56.8%(w)and its structure was identified by 1H-NMR and ESIMS.Conclusions Dichloromethane was used as the solvent in the amidation to replace the dangerous and toxic mixture of cyclohexane-dioxane used in literatures,and pyridine was employed as the base instead of N,N-dimethylaniline or potassium carbonate.This easily operated and much safe process could also improve the yield of the reaction.Moreover,potassium t-butoxide was employed for the substitution reaction to replace the dangerous NaH or expensive NaHMDS." @default.
- W2377433269 created "2016-06-24" @default.
- W2377433269 creator A5004269850 @default.
- W2377433269 creator A5027611703 @default.
- W2377433269 creator A5044770286 @default.
- W2377433269 creator A5057396658 @default.
- W2377433269 date "2010-01-01" @default.
- W2377433269 modified "2023-09-23" @default.
- W2377433269 title "Preparation of nevirapine" @default.
- W2377433269 hasPublicationYear "2010" @default.
- W2377433269 type Work @default.
- W2377433269 sameAs 2377433269 @default.
- W2377433269 citedByCount "0" @default.
- W2377433269 crossrefType "journal-article" @default.
- W2377433269 hasAuthorship W2377433269A5004269850 @default.
- W2377433269 hasAuthorship W2377433269A5027611703 @default.
- W2377433269 hasAuthorship W2377433269A5044770286 @default.
- W2377433269 hasAuthorship W2377433269A5057396658 @default.
- W2377433269 hasConcept C134121241 @default.
- W2377433269 hasConcept C135731615 @default.
- W2377433269 hasConcept C155647269 @default.
- W2377433269 hasConcept C161790260 @default.
- W2377433269 hasConcept C178790620 @default.
- W2377433269 hasConcept C185592680 @default.
- W2377433269 hasConcept C191897082 @default.
- W2377433269 hasConcept C192562407 @default.
- W2377433269 hasConcept C2777998946 @default.
- W2377433269 hasConcept C2778439535 @default.
- W2377433269 hasConcept C2779485729 @default.
- W2377433269 hasConcept C2780291738 @default.
- W2377433269 hasConcept C2780400988 @default.
- W2377433269 hasConcept C2780471494 @default.
- W2377433269 hasConceptScore W2377433269C134121241 @default.
- W2377433269 hasConceptScore W2377433269C135731615 @default.
- W2377433269 hasConceptScore W2377433269C155647269 @default.
- W2377433269 hasConceptScore W2377433269C161790260 @default.
- W2377433269 hasConceptScore W2377433269C178790620 @default.
- W2377433269 hasConceptScore W2377433269C185592680 @default.
- W2377433269 hasConceptScore W2377433269C191897082 @default.
- W2377433269 hasConceptScore W2377433269C192562407 @default.
- W2377433269 hasConceptScore W2377433269C2777998946 @default.
- W2377433269 hasConceptScore W2377433269C2778439535 @default.
- W2377433269 hasConceptScore W2377433269C2779485729 @default.
- W2377433269 hasConceptScore W2377433269C2780291738 @default.
- W2377433269 hasConceptScore W2377433269C2780400988 @default.
- W2377433269 hasConceptScore W2377433269C2780471494 @default.
- W2377433269 hasIssue "3" @default.
- W2377433269 hasLocation W23774332691 @default.
- W2377433269 hasOpenAccess W2377433269 @default.
- W2377433269 hasPrimaryLocation W23774332691 @default.
- W2377433269 hasRelatedWork W2684013408 @default.
- W2377433269 hasRelatedWork W2772972091 @default.
- W2377433269 hasRelatedWork W2812179403 @default.
- W2377433269 hasRelatedWork W2838657983 @default.
- W2377433269 hasRelatedWork W2842073373 @default.
- W2377433269 hasRelatedWork W2850738713 @default.
- W2377433269 hasRelatedWork W2853461502 @default.
- W2377433269 hasRelatedWork W2868764139 @default.
- W2377433269 hasRelatedWork W2877466165 @default.
- W2377433269 hasRelatedWork W2927866163 @default.
- W2377433269 hasRelatedWork W2932262921 @default.
- W2377433269 hasRelatedWork W2943115280 @default.
- W2377433269 hasRelatedWork W2944135219 @default.
- W2377433269 hasRelatedWork W2987180399 @default.
- W2377433269 hasRelatedWork W3002268145 @default.
- W2377433269 hasRelatedWork W3094759876 @default.
- W2377433269 hasRelatedWork W3097542301 @default.
- W2377433269 hasRelatedWork W3148188189 @default.
- W2377433269 hasRelatedWork W3151261688 @default.
- W2377433269 hasRelatedWork W3151545679 @default.
- W2377433269 hasVolume "27" @default.
- W2377433269 isParatext "false" @default.
- W2377433269 isRetracted "false" @default.
- W2377433269 magId "2377433269" @default.
- W2377433269 workType "article" @default.