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- W2377446384 abstract "Objective To observe the effect of ulinastatin(ULI)and taxotere(TXT) on proliferation and invasion of human breast cancer MDA-MB-231 cells as well as expressions of IL-6,IL-8 and TNF-α.Methods The estrogen receptor-negative MDA-MB-23l cells cultured in vitro were randomly divided into blank control,ULI(800 U / ml),TXT(3.7 μg / ml) and ULI + TXT groups,and determined for the transcription levels of IL-6,IL-8 and TNF-α mRNAs by fluorescent quantitative RT-PCR,for proliferation ability by MTT method,and for invasion ability by Transwell chamber assay.Results Both TXT and ULI inhibited the expressions of IL-6,IL-8 and TNF-α genes as well as the proliferation and invasion of MDA-MB-231 cells,while the inhibition ability of ULI was lower than that of TXT.However,TXT combined with ULI showed the strongest inhibitory effect in all the four groups.Conclusion ULI inhibited the proliferation and invasion of human breast cancer MDA-MB-231 cells by a mechanism which might be associated with the down-regulation of expressions of IL-6,IL-8 and TNF-α genes." @default.
- W2377446384 created "2016-06-24" @default.
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- W2377446384 date "2011-01-01" @default.
- W2377446384 modified "2023-09-25" @default.
- W2377446384 title "Effect of Ulinastatin and Taxotere on Proliferation and Invasion of Human Breast Cancer Line MDA-MB-231 Cells and Relevant Mechanism" @default.
- W2377446384 hasPublicationYear "2011" @default.
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