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- W2377464907 abstract "Objective To investigate the synergistic effect of scopadulciol(SDC)on the killing effect on antitumor actions by Ad-hTERT-HSV-tk/GCV suicide gene system on prostate cancer cells in vitro.Methods We successfully built the model of human prostate cancer xenografts in BALB/C nude mouse.The BALB/C nude mice were treated respectively with AdhTERT-HSV-tk or GCV in combination with SDC in different doses and different concentrations.The indexes of tumor volume,tumor mass,relative tumor curative effect were evaluated.ResultsThe growth rate of tumor volume of four treatment groups could be significantly inhibited after treatment.The tumor volume and tumor mass of group A,group B,group C and group D were significantly lower than the other groups(P0.01).The relative tumor curative effect of group A,group B,and group C,which were added SDC,were significantly higher than that of group D(P0.01).Conclusion The synergistic effect of SDC was significantly shown in treatment of human prostate cancer cells by TK-dependent GCV." @default.
- W2377464907 created "2016-06-24" @default.
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- W2377464907 date "2015-01-01" @default.
- W2377464907 modified "2023-09-22" @default.
- W2377464907 title "Synergistic effect of scopadulciol in treatment of human prostate cancer in vitro by thymidine kinase-dependent ganciclovir" @default.
- W2377464907 hasPublicationYear "2015" @default.
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