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- W2377469071 abstract "Objective To investigate the changes of brain serotonin and tryptophan in rats treated with chronic unpredicted stresses.Methods Twenty rats were divided into two groups, with 10 exposed to 21 consecutive days of unpredicted chronic stresses as depression models, and 10 as normal controls. The concentrations of serotonin and tryptophan in hippocampus, frontal cortex, hypothalamus and striatum were detected with high performance liquid chromatography coupled with fluorescence detection.Results (1)There was significantly differences in total activity between the two groups (P0.001). (2) The concentrations of serotonin in hippocampus and frontal cortex in depression model group (0.34±0.08) ng/mg and (0.55±0.06) ng/mg were significantly lower than that in normal group (0.46±0.06) ng/mg and (0.66±0.09) ng/mg;P0.01, while the concentrations of tryptophan in hippocampus and frontal cortex in depression model group (3.76±0.34) ng/mg and (4.08±0.51) ng/mg were higher than that in normal controls (3.23±0.38) ng/mg and (3.49±0.44) ng/mg ;P0.05. There were no significant difference between the two groups in the concentrations of tryptophan and serotonin in hypothalamus and striatum (P0.05).Conclusion The low synthesis of serotonin in brain may be one of the pathogenesis of depression." @default.
- W2377469071 created "2016-06-24" @default.
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- W2377469071 date "2006-01-01" @default.
- W2377469071 modified "2023-09-27" @default.
- W2377469071 title "Changes of brain tryptophan and serotonin in rats treated with chronic unpredicted stresses" @default.
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