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- W2377509258 abstract "Objective To investigate the clinical effects of estradiol valerate alone or in combination with folic acid and vitamin B12 on perimenopausal depression.Methods Seventy patients with perimenopausal depression were randomized into two groups,with 35 patients in each group.The control group was orally given estradiol valerate(0.5mg,once per day)alone for 28 days.The treatment group was orally given combined treatment with estradiol valerate(0.5mg,once per day),folic acid(0.4mg,3times per day)and vitamin B12(25μg,3times per day)for 28 days.Clinical efficacy and adverse reactions were observed in both groups.In addition,the severity of depression was assessed using the Hamilton Depression Rating Scale(HAMD)before treatment,after treatment for 2and 4weeks,and at the second and fourth week of follow-up.Results The total effective rate in treatment group was significantly higher than that in control group(85.7%vs 65.7%,P0.05).HAMD scores significantly decreased after treatment for 2and 4weeks and at the second and fourth week of follow-up in both groups,and the decrease in treatment group was more obvious than that in control group(P0.05 or P0.01).Conclusion Estradiol valerate combined with folic acid and vitamin B12 is superior to estradiol valerate alone for treating perimenopausal depression." @default.
- W2377509258 created "2016-06-24" @default.
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- W2377509258 date "2014-01-01" @default.
- W2377509258 modified "2023-09-24" @default.
- W2377509258 title "Estradiol Valerate Alone or in Combination with Folic Acid and Vitamin B_(12) for Perimenopausal Depression" @default.
- W2377509258 hasPublicationYear "2014" @default.
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