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- W2377509512 abstract "OBJECTIVE: To study the effects of copper aspirin complex (CuAsp) on thrombosis and on platelet neutrophile adhesion.METHODS:The methods of Kohier et al ,Hamburger et al and Jungi et al were applied to observe the effects of CuAsp on thrombosis in mice and platelet neutrophile adhesion in rats. RESULTS:CuAsp 10 mg·kg 1 ·d 1 ig for 7d markedly decreased the male mouse mortality caused by injec tion of 80 mg·kg 1 arachidonic acid in the tail vein from 80.0% in vehicle group to 13.3%. CuAsp also significantly inhibited the adhesion of neutrophiles to platelets activated by arachidonic acid or thrombin in vitro , IC 50 were 41.5 and 54.6 μmol·L 1 .CONCLUSION:It is demonstrated that CuAsp inhibited platelet neutrophile adhesion and resulted in more potent antithrombotic activity." @default.
- W2377509512 created "2016-06-24" @default.
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- W2377509512 date "2000-01-01" @default.
- W2377509512 modified "2023-09-27" @default.
- W2377509512 title "EFFECTS OF COPPER ASPIRIN COMPLEX ON THROMBOSIS AND PLATELET NEUTROPHILE ADHESION" @default.
- W2377509512 hasPublicationYear "2000" @default.
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