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- W2377512382 abstract "Objective To observe the effect of propofol combined with dexamethasone on the inflammatory factors of early sepsis in rats.Methods Rats were randomly assigned into group N,group L,group LD,group LP,and group LPD,which underwent intravenous injection through the tail vein with 10 ml 0.9% Saline,lipopolysaccharide(LPS),LPS and dexamethasone,LPS and propofol,LPS and propofol plus dexamethasone,respectively.All the rats were killed through anesthesia,and their abdominal aortic blood were detected for the levels of serum tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6) and interleukin-10(IL-10) by enzyme-linked immunosorbent assay(ELISA).Results In group L,the levels of TNF-α,IL-1β and IL-6 was significantly higher than that in group N,while the levels of IL-10 was significantly lower(P0.05).Compared with group L,the levels of TNF-α,IL-1β and IL-6 were significantly decreased in group LD,group LP and group LDP,with levels of IL-10 significantly increased..Compared with the group LD and group LP,the levels of TNF-α,IL-1β and IL-6 were significantly decreased in group LDP,with IL-10 significantly increased.Conclusion LPS could induce the release of TNF-α,IL-1β and IL-6,while inhibit the expression of IL-10.After the intervention of dexamethasone and propofol,the levels of TNF-α,IL-1β and IL-6 were significantly reduced,with IL-10 significantly increased.The combination of dexamethasone and propofol had significant protective effect on rats in the early stage of sepsis." @default.
- W2377512382 created "2016-06-24" @default.
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- W2377512382 date "2011-01-01" @default.
- W2377512382 modified "2023-09-25" @default.
- W2377512382 title "Effect of propofol combined with dexamethasone on the inflammatory factors of early sepsis in rats" @default.
- W2377512382 hasPublicationYear "2011" @default.
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