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- W2377515351 abstract "Objective:To preliminarily investigate the collaterals damnification mechanism of cerebral infarction through detecting the dynamic expression of 6-Keto-PGF1α/TXB2 and VEGF in cerebral cortex of rats after focal cerebral ischemia reperfusion.Methods: Rat models of focal cerebral ischemia and reperfusion were established by thread ligation in middle cerebral artery.The levels of 6-Keto-PGF1α and TXB2 of cerebral cortex at different time point were measured by radio-immunoassay,and the expressions of VEGF were assayed by using immunohistochemical staining and image analysis.Result: Compared with the sham group,the model group 6-Keto-PGF1α began to decrease after reperfusion at f irst,and reach the lowest at 3h(P0.05),then began to increase and reach peak at 24h(P0.05).TXB2 concentration obviously increased and reach peak at 24 h(P0.01).6-Keto-PGF1α/TXB2 ratio markedly decreased and reach the lowest at 3h.VEGF obviously increased and reach peak at 24h(P0.01).Conclusion:The disequilibrium of 6-Keto-PGF1α and TXB2 is a important point of the pathological lesion of cerebral ischemia,VEGF participates the pathological lesion and reparative process of cerebral ischemia,and the disorder of microcirculation,which represented by those dynamic pathological changes,can re? ect the collaterals damnifi cation mechanism of cerebral infarction." @default.
- W2377515351 created "2016-06-24" @default.
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- W2377515351 date "2008-01-01" @default.
- W2377515351 modified "2023-09-23" @default.
- W2377515351 title "Preliminarily investigating the collaterals damnif ication mechanism of cerebral infarction through detecting the dynamic expression of 6-Keto-PGF_(1α)/TXB_2 and VEGF in cerebral cortex of rats after cerebral ischemia reperfusion" @default.
- W2377515351 hasPublicationYear "2008" @default.
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