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- W2377535313 abstract "To observe the analgesic effect of Jiedu Tuoyin Decoction (JTD) and its influence on reproduction of morphine dependence rats. JTD is composed of Rhizoma Coptidis, Radix Rehmanniae, Radix Aconiti, Radix Astragali, Radix Codonopsis, Ramulus Uncariae cum Uncis, etc..Sixty rats were randomly allocated to six groups: normal saline group (Group A), morphine and normal saline group (Group B), morphine and clonidine group(Group C),morphine and low dosage of JTD group (Group D), morphine and moderate dosage of JTD group (Group E) and morphine and high dosage of JTD group (Group F).Content of β endophin(β EP) in hypothalamus and plasma, substance P (SP) content in ganglion nodosum(GN) and nucleus tractus solitarii(NTS) and serum levels of sexual hormones were examined.(1) β EP content in hypothalamus of morphine dependence rats was lower and SP content in ganglion nodosum and nucleus tractus solitarii was higher than that of normal rats (P0 01);β EP content in hypothalamus of Group F and in plasma of Group E and Group F was increased and SP content in GN and NTS of Group F was decreased (P0 05 or P0 01 as compared with Group B). (2) Serum levels of follicle stimulating hormone (FSH), estradiol (E 2) and prolactin (PRL) in morphine dependence female rats and serum level of testosterone (T) in morphine dependence male rats was lower than that of normal rats (P0 01); Serum levels of FSH, E 2 and PRL of female rats and serum T level of male rats in Group E and Group F was increased (P0 05 or P0 01 as compared with Group B) and the changes of serum levels of luteotrophic hormone(LH) and PRL in Group E and Group F stayed insignificant.[Conclusion]JTD can eliminate the withdrawal symptoms in morphine dependence rats probably by regulating the function of the axis of hypothalamus pituitary adrenal gland." @default.
- W2377535313 created "2016-06-24" @default.
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- W2377535313 date "2002-01-01" @default.
- W2377535313 modified "2023-09-25" @default.
- W2377535313 title "Analgesic Effect of Jiedu Tuoyin Decoction and Its Influence on Reproduction of Morphine-dependence Rats" @default.
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