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- W2377544638 abstract "Purpose:We evaluated the sensitivity and specificity of p53 antibodies (p53-Ab) as a preoperative tumor marker and as a prognosis marker in colorectal cancer patients and we also investigated whether p53-Ab production is dependent on p53 protein overexpression in tumor tissue.Methods:Serum samples from 178 colorectal cancer patients and 40 healthy controls were tested for the presence of p53-Ab by using an ELISA kit. Expression of p53 protein in tumors was determined using mouse anti-human p53-Ab.Results:Serum p53-Ab was detected in 18.54% of patients while all controls were negative. A strong correlation between p53-Ab production and p53 protein expression was observed: 69.7%of p53-Ab positive cases had tumors positive for p53 vs 30.3%of p53-Ab negative cases. There was also a significant predominance of p53-Ab positive cases in Dukes ’ stages B (16/71,22.54%), C (12/55,21.82%)and D(5/30,16.67%)over stage A. No difference in patients’ age, sex and localization was found between the p53-Ab positive and negative groups. Recurrence of cancer did not differ between p53-Ab positive and negative patients after a median follow-up of 13.5 months and also median survival time did not vary significantly.Conclusions:There was a significant correlation between p53-Ab production in serum and p53 protein expression in tumor tissue. Because of their low sensitivity (18.54%) p53-Ab are not suitable as a preoperative tumor marker. However, their high specificity (100%) and their potential for early diagnosis of a tumor relapse makes them valuable for postoperative monitoring during follow-up in p53- Ab positive patients.[" @default.
- W2377544638 created "2016-06-24" @default.
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- W2377544638 date "2004-01-01" @default.
- W2377544638 modified "2023-09-27" @default.
- W2377544638 title "Clinical significance of p53 expression in colorectal cancer patients" @default.
- W2377544638 hasPublicationYear "2004" @default.
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