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- W2377558729 abstract "Objective To investigate the changes of endothelium-dependent flow-mediated vasodilation ( FMD) and endothelium-independent nitroglycein-mediated vasodilation( NMD) of brachial artery in patients with the early stage of type 2 diabetes mellitus. Methods Fifty type 2 diabetic patients without large vascular complications ( DM ) and 34 healthy controls ( NC ) were included in the study. High resolution ultrasound was performed to measure FMD and NMD,and laboratory data such as fasting blood glucose ( FBG) ,hemoglobin A1c( HbA1c) ,total cholesterol( TC) ,triglyceride( TG) ,low density lipoprotein cholesterol ( LDL-C) ,high density lipoprotein cholesterol( HDL-C) ,apolipoprotein A1( ApoA1) ,apolipoprotein B( ApoB) , lipoprotein α( Lpα) ,serum ferritin ( SF) and oxidized low density lipoprotein ( ox-LDL) were also analyzed. Results The FBG,HbA1c,TC,TG,LDL-C,HDL-C,ApoB,Lpα,SF and ox-LDL were( 8. 58 ± 1. 90) mmol /L, ( 8. 66 ±2. 60) %,( 5. 43 ± 0. 79) mmol/L,( 1. 96 ± 0. 94) mmol/L,( 3. 22 ± 0. 73) mmol/L,( 1. 02 ± 0. 23) mmol / L,( 0. 87 ± 0. 23) g / L,( 215. 69 ± 81. 9 ) mg / L,( 279. 19 ± 92. 68) ng / ml,( 24. 95 ± 7. 2) μg / dl in DM group,( 5. 31 ± 0. 42) mmol / L,( 5. 16 ± 0. 41) % ,( 4. 64 ± 0. 54) mmol / L,( 1. 45 ± 0. 62) mmol / L,( 2. 32 ±0. 55) mmol/L,( 1. 27 ±0. 25 ) mmol/L,( 0. 69 ±0. 16) g/L,( 178. 26 ±20. 2 ) mg/L,( 151. 21 ± 84. 37 ng / ml,( 10. 62 ± 8. 46) μg / dl in NC group,there were significant difference between the two groups ( t =2. 653,2. 986,2. 252,2. 224,2. 321,2. 320,2. 096,2. 786,2. 965,2. 996,all P 0. 05) . Compared with NC group,FMD and NMD in DM group were significantly lower[( 7. 10 ± 2. 23) % vs ( 4. 11 ± 1. 13) % ,t = 2. 217,P 0. 01]and[( 20. 22 ± 4. 68) % vs ( 13. 02 ± 4. 25) % ,t = 2. 121,P 0. 05],whereas laboratory parameters including FBG,TC,TG,LDL-C,ApoB,Lpα,HbA1c,SF and ox-LDL were significantly higher. Taking FMD and NMD as the dependent variables,multi-variable regression analysis indicated that FMD was significantly related with TC,ApoB,SF,and ox-LDL level ( r = 0. 681,P 0. 05 ) ,whereas NMD was significantly related with Tc and ApoB( r = 0. 642,P 0. 05) . Conclusion FMD was impaired in patients with type 2 diabetes mellitus possibly related with the increased levels of TC,ApoB,SF and ox-LDL." @default.
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- W2377558729 date "2012-01-01" @default.
- W2377558729 modified "2023-09-25" @default.
- W2377558729 title "Ultrasound evaluation of endothelium-dependent vasodilation function and analysis of the related influencing factors in patients with type 2 diabetes mellitus" @default.
- W2377558729 hasPublicationYear "2012" @default.
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