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- W2377591798 abstract "Objective: To investigate the inhibiting effect of Gemcitabine(GEM)(5 mg/ml) on posterior capsule opacification(PCO).Methods: 12 New Zealand rabbits(12 eyes) were randomly divided into treatment group and control group.All the rabbits were given extracapsular cataract extraction(ECCE) and intraocular lens(IOL) implantation.During operation,the treatment group was received hydrodissection by using a solution containing GEM;the control group was given irrigating solution for hydrodissection.In the four-week follow-up after operation,the PCO and the change of cornea and anterior chamber's exudation were observed and compared between the control group and the treatment group.Results: At 1st,3rd,and 7th day after operation,there was no difference in corneal edema between the two groups.PCO appeared in both groups two weeks after operation.Four weeks after operation,the PCO in the eyes of treatment group was markedly lower than that of control group.Conclusion: In this study,it shows that using GEM(5 mg/ml),in ECCE and IOL implantation,can effectively reduce PCO,although the intraocular application of GEM could induce drug toxicity to intraocular tissues,which can be avoid or relieved by improving medication and enhancing of protective measures.So it should be a safe and effective drug in the prevention of after-cataract." @default.
- W2377591798 created "2016-06-24" @default.
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- W2377591798 date "2006-01-01" @default.
- W2377591798 modified "2023-09-24" @default.
- W2377591798 title "Experimental Study of Gemcitabine Intraocular Use in Inhibition of Posterior Capsule Opacification" @default.
- W2377591798 hasPublicationYear "2006" @default.
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