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- W2377599653 abstract "objective To observe the synergistic effects of berberine hydrochloride and fluconazol on drug-resistant Candida albicans.Methods Ninety ICR mouse were randomly divided into 6 groups(15 in each group).Two hours after the systemic infection model was made,drugs were intraperitoneally given at 0.2 ml/10 g qd for 7 days.The viable bacteria in kidney biopsy sample was calculated as log10CFU/g.Results The mean survival time was no statistically significant between mouses(3.5days,with berberine hydrochloride 9 mg/kg,viable bacteria 6.566) and mouses(3.4days,with no drugs,viable bacteria 6.462)(P0.05).The mean survival time was statistically significant between mouses(9.9days,with fluconazol 0.5mg/kg,viable bacteria 6.566) and mouses(with berberine hydrochloride 9 mg/kg)(P0.05).The mean survival time was 12.7days in mouse administered with berberine hydrochloride(1 mg/kg)and fluconazol(0.5 mg/kg)(viable bacteria 5.723),16.1 days in mouses with berberine hydrochloride(3 mg/kg)and fluconazol(0.5 mg/kg)(viable bacteria 5.645),18.7days in mouses with berberine hydrochloride(9 mg/kg)and fluconazol(0.5 mg/kg)(viable bacteria 4.967).The combined therapy resulted in longer survival than single drug therapy(P0.05) and increase in dosaged berberine hydrochloride led to the same results(P0.05 or 0.01).Conclusion Berberine hydrochloride combined with fluconazol has synergistic effects on drug-resistant Candida albicans with moderate dosage of berberine hydrochloride combined with fluconazol leading to enhanced effect." @default.
- W2377599653 created "2016-06-24" @default.
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- W2377599653 date "2011-01-01" @default.
- W2377599653 modified "2023-09-25" @default.
- W2377599653 title "The synergistic effects of berberine hydrochloride and fluconazol on drug-resistant Candida albicans:An experimental study" @default.
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