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- W2377600388 abstract "Objective To explore the clinical pathological characteristics and the immunosup- pressant conversion treatment on chronic allograft nephropathy(CAN).Methods Twenty cases of CAN diagnosed clinically received biopsy and then pathological evaluation based on Banff 97 schema according to glomerulosclerosis,interstitial fibrosis,tubular atrophy and arteriopathy.All cases had received cyclosporine(CsA)-based immunosuppressive protocol.Three cases were converted into ta- crolimus(FK506)-based protocol and 17 into sirolimus(Sir)-based protocol.The changes in renal function were compared before and after conversion.Results Twenty cases suffered from CAN char- acterized by glomerulosclerosis,interstitial fibrosis and tubular atrophy.Subclinical rejection was present in 9 of them and was responsive by high-dose methylprednisolone bolus treatment.The graft function and the treatment outcome were not correlated with the severity of interstitial fibrosis and tu- bular atrophy,meanwhile the cases with less than 30 % glomeruloscelrosis enjoyed relatively good prognosis but more than 50% glomerulosclerosis indicated graft loss soon.Combined with mycophe- nolate mofetil(MMF),basic immunosuppressant conversion of CsA to Sir or FK506 resulted in de- creased or stable blood creatinine.Conclusion The rate of glomerulosclerosis may evaluate the severity and the prognosis of CAN.The treatment protocol of CAN consists of reversion of subclinical rejec- tion,CsA withdrawl and combined therapy of Sir and MMF." @default.
- W2377600388 created "2016-06-24" @default.
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- W2377600388 date "2007-01-01" @default.
- W2377600388 modified "2023-09-23" @default.
- W2377600388 title "The clinical pathological characteristics and immunosuppresant conversion treatment of chronic allograft nephropathy" @default.
- W2377600388 hasPublicationYear "2007" @default.
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