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- W2377602363 abstract "Objective: To investigate the clinical significance of the core promoter(CP) mutant(T1762A1764) of hepatitis B virus (HBV) and its effects on the response to interferon in patients with chronic hepatitis B (CHB).Methods: CP region were sequenced directly from sera of four cases of chronic asymptomatic HBV carriers(AsC) and twenty-seven patients with CHB,after amplication by the polymerase chain reaction(PCR).The content of serum HBV DNA was tested with quantitive PCR technique to evaluate the effectiveness of clinical antiviral treatment.Results: The double mutant was detected in 14 of 27 patients with CHB and the prevalence of mutant in patients with obvious liver damage was significantly higher than in patients with mild liver damage.The mutant viral strain prevailed over wild type one(WT) during survival.After α-interferon treatment,the amount of serum HBV DNA significantly declined and seroconversion rates of HBeAg positive to negative and HBV DNA positive to negative significanlty rised in CHB patients infected with dominant HBV strain with the double mutant as compared to controls.Resequencing showed that the dominant of the double mutant was replaced by WT in 3 out of 4 cases after interferon administration.Conclusion:HBV strain with the double mutant of nucleotides 1762 and 1764 in the CP seem to be more wensitive to α-interferon compared with WT." @default.
- W2377602363 created "2016-06-24" @default.
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- W2377602363 date "2001-01-01" @default.
- W2377602363 modified "2023-09-24" @default.
- W2377602363 title "THE CORE PROMOTER MUTANT(T1762 A1764) OF HEPATITIS B VIRUS:CLINICAL SIGNIFICANCE AND ITS EFFECTS ON THE RESPONSE TO INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS B." @default.
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