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- W2377607310 abstract "Objective To observe the expression of receptor 1(CB1R) in the rat model of nonalcoholic fatty liver disease(NAFLD) and evaluate the therapeutic role of CB1R antagonist Rimonabant in NAFLD,then study that the possible mechanisms.Methods After fed with HSHF diet for 30 days,the rats randomly allocated in several groups,then injected daily with Rimonabant for 8 weeks.Serum enzymes of liver function and serum lipid were detected.Liver steatosis were evaluated by histopathology.The expressions of CB1R in the liver tissue were evaluated by immunohistochemical technique.Results The expression of CBlR in model groups was higher than that of groups(P 0.01).After an intervention with Rimonabant,the liver steatosis gradually reversed and serum leptin,serum TNF-α,serum alanine aminotransferase(ALT),serum aspartate aminotransferase(AST),triglyceride(TG),total cholesterol(TC) were significantly decreased(P 0.01).Conclusion The model of the NAFLD is successfully induced by HSHF diet for 30 days.CB1 receptor antagonist will be a promising target for the pharmacologic treatment approach of NAFLD." @default.
- W2377607310 created "2016-06-24" @default.
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- W2377607310 date "2013-01-01" @default.
- W2377607310 modified "2023-09-24" @default.
- W2377607310 title "Role of the endocannabinoid receptor 1 in the rat of non-alcoholic fatty liver disease" @default.
- W2377607310 hasPublicationYear "2013" @default.
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