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- W2377613656 abstract "AIM:To study the pharmacokinetics of balofloxacin tablets alter single or multiple doses orally taken in Chinese healthy volunteers.METHODS:Twelve Chinese healthy volunteers (6 males,6 females) were given single splitting of oral doses of 100 mg,200 mg,400 mg and multiple oral doses (200 mg daily for 5 days) of balofloxacin tablets.The concentrations of balofloxacin in plasma were measured by HPLC-UV and the pharmacokinetic parameters were calculated by DAS 2.0 software.RESULTS:The main pharmacokinetic parameters of balofloxacin tablet as splitting single orally taken doses for 100 mg,200 mg and 400 mg were c_(max) (1.42±s0.25),(2.9±0.6) and (5.6±1.4) mg·L~(-1);t_(max) (0.8±0.4),(0.9±0.4) and (1.2±0.4) h;t_(1/2) (7.4±2.7),(7.2±1.1) and (8.4±2.2) h;AUC_(0-∞) (9.8±1.7),(21±3) and (44±12) mg·h·L~(-1), respectively.Those for multiple orally taken dose were c_(max) (2.9±0.8) mg·L~(-1),t_(max) (0.83±0.19) h,t_(1/2) (8.2±2.0) h,AUC_(0-∞) (21±5) mg·h·L~(-1) and FI (93.7±1.4)%.CONCLUSION:The plasma concententration-time data of balofloxacin in human being coincide with a two compartment model and a first order kinetic processes in disposition in Chinese volunteers." @default.
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- W2377613656 date "2007-01-01" @default.
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- W2377613656 title "Pharmacokinetics of balofloxacin tablets in healthy volunteers" @default.
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