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- W2377647534 abstract "Background and objective Aquaporin2(AQP2) acts as a channel in the water homeostasis,playing an important role in many pathological processes.This study was to investigate the effect of vasopressin (AVP) on the expression of AQP2 in WKY rats kidney.Methods Sixteen male Wistar-Kyoto rats were randomly to receive: AVP [WKY_(AVP),2.5 U/(kg·d)] or identical volume of saline (WKY_ctrl)) given peritoneally.Seven days after ad- ministration,plasma AVP was measured by using radioimmunoassay.The expression levels of AQP2 mRNA and protein in kidney were assessed with RT PCR and immunohistochemical method.Results 7 days after administra- tion of vasopressin,renal levels of AQP2 mRNA (0.68±0.14 vs 0.39±0.11,P0.05) and AQP2 protein expres- sion [0.71±0.09 vs 0.42±0.12,P0.05) were increased when plasma concentrations of AVP (65.7±5.2 vs 51.2 ±7.9 ng/L,P0.05) were significantly higher in WKY_(AVP) group than that in WKY_(ctrl) group.Conclusion The expression of AQP2 in kidney tissue of WKY is at least partially upregulated by AVP,and may be one of mechnism of AVP in regulating metabolism of water,suggesting that AQP2 may be a potential interventional target in treating some cardiovascular diseases such as congestive heart failure and hypertension." @default.
- W2377647534 created "2016-06-24" @default.
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- W2377647534 date "2008-01-01" @default.
- W2377647534 modified "2023-09-24" @default.
- W2377647534 title "Effect of Vasopressin on the Expression of Aquaporin 2 in Kidney in WKY Rats" @default.
- W2377647534 hasPublicationYear "2008" @default.
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