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- W2377647819 abstract "Objective To investigate the relationship between the variance at codon 54 of fatty acid binding protein 2 gene (FABP2) and abnormal postprandial triglyceride (TG) metabolism in essential hypertension (EH). Methods In 50 patients with EH and 30 normal subjects(NS), total cholesterol, HDL cholesterol, LDL cholesterol in fasting serum and serum triglyceride before and 2?4?6?8 hours after a standardized fat loading were measured. Triglyceride peak response (TGPR) and the area under triglyceride curve(TG AUC) over 8 hours were taken as the index of abnormal TG metablism. Using polymerase chain reaction (PCR), the variants were screened with the restrict fragment length polymorphism (RFLP) analysis. Results TGPR and TG AUC were higher in EH than those in NS(TGRP: 20 02±6.25 vs 9.61±2.27 mmol/L, P 0 01;TG AUC: 4.15±2.82 vs 2 05±1.31 mmol/L, P 0 01). The frequencies of threonine encoding allele (Thr54) was of no difference between EH and NS (0 28 vs 0 25, P 0 05). Thr54 homozygotes and Thr54 heterozygotes demonstrated higher TG AUC and TGPR than wild type (Ala54 homozygotes) in EH (TG AUC:28.2±6 11?21 9±6 16 vs 13 9±6 07 mmol/L, P 0 05;TGPR: 7 56±2 67?4 20±1 62 vs 2 34±1 47 mmol/L, P 0 05). Significantly higher TG AUC and TGPR was manifested in Thr54 homozygotes than in Thr 54 heterozygotes. Conclusion Abnormal postprandial triglyceride metabolism was shown in patients with EH FABP2 threonine encoding allele was associated with abnormal postprandial triglyceride metabolism." @default.
- W2377647819 created "2016-06-24" @default.
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- W2377647819 date "2002-01-01" @default.
- W2377647819 modified "2023-09-25" @default.
- W2377647819 title "The Relationship Between Polymorphism of Fatty Acid-binding Protein 2 Gene and Abnormal Postprandial Triglyceride Metabolism in Essential Hypertension" @default.
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