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- W2377672375 abstract "Objective: To study the effect of rosiglitazone on 3T3-L1 adipocyte and the mechanisms. Methods: The 3T3-L1 adipocytes were cultured and induced to differentiation and maturity in vitro, and glucokinase was added to make an oxidative model. Then the adipocytes were treated by rosiglitazone at different doses and for different time. The expression of visfatin was determined by ELISA. Results: Visfatin expression was decreased along with the increase dose of the glucokinase in a concentration-dependent manner (P0.05). With the pretreatment of oxidative stress, visfatin expression was increased according to the increasing doses of rosiglitazone (P0.05). As the extension of rosiglitazone effect, expression of visfatin experienced decreasing-increasing process, and was parallel with the changes of oxidative stress. Conclusion: Rosiglitazone can increase visfatin expression in 3T3-L1 adipocyte by reducing oxidative stress, which could play a role in the treatment of insulin resistance in obesity related diabetes." @default.
- W2377672375 created "2016-06-24" @default.
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- W2377672375 date "2011-01-01" @default.
- W2377672375 modified "2023-09-25" @default.
- W2377672375 title "Rosiglitazone Influences Expression of Visfatin in 3T3-L1 Adipocytes Through Inhibiting Oxidative Stress" @default.
- W2377672375 hasPublicationYear "2011" @default.
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