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- W2377672393 abstract "OBJECTIVE To prepare the insulin(Ins)- loaded micelles using γ- glutamic acid(γ- PGA) graft derivatives(PGA-LA) as the carrier materials. METHODS PGA- LA was obtained with different hydrophobic modification degrees(GD values) and the critical micelle concentration(CMC) was measured. Ins- loaded micelles were prepared by dialysis method,and their characterization was studied. Then,circular dichroism(CD) was applied to investigate the effect of DMSO on the secondary structure of Ins and coomassie brilliant blue(CBB) stains were used to investigate the mechanism of micelles formation. RESULTS PGA- LA with higher GD value of 70. 23% had smaller CMC value of 0. 11 μg·mL- 1. CD spectrum confirmed that DMSO had no influence on the secondary structure of Ins. Then,CBB spectrum confirmed the stronger hydrophobic interaction between Ins and PGA- LA with higher GD value,and it contributed to decreasing the particle size of Ins- loaded micelles. CONCLUSION Ins- loaded micelles prepared with GD value of 70. 23% exhibites good particle size and size distribution,as well as high encapsulation efficiency and drug loading." @default.
- W2377672393 created "2016-06-24" @default.
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- W2377672393 date "2014-01-01" @default.
- W2377672393 modified "2023-09-26" @default.
- W2377672393 title "Preparation and characterization of insulin-loaded micelles" @default.
- W2377672393 hasPublicationYear "2014" @default.
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