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- W2377674927 abstract "Objective To identify cancer metastasis related genes in colon cancer and to analyze part of them by cDNA microarray analysis,and to explore its molecular mechanism.Methods Two samples of colon cancer tissues of non-metastasis and 2 of metastasis were taken and freshly frozen respectively.cDNA microarray with more than 16k genes was used.Genes were considered to be up-or down-regulated when the fluorescent intensity ratio was over 2-fold in over 50% of the samples(P0.05).Results Compared with those of non-metastatic colon cancer tissues,there were a total of 112 genes up-regulated and 84 genes down-regulated in already metastatic colon cancer tissues.The function of these genes refered to cell binding,cell cycle,transduction,cell structural-moleculor,and so on.Conclusion Gene expression profiling by cDNA microarray analysis provides molecular understanding of biological properties of cancer." @default.
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- W2377674927 date "2010-01-01" @default.
- W2377674927 modified "2023-09-26" @default.
- W2377674927 title "Microarray analysis of gene spectrum related to metastasis of colon cancer" @default.
- W2377674927 hasPublicationYear "2010" @default.
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