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- W2377690069 abstract "Objective To investigate the clinicopathological characteristics and prognosis of hormone receptor breast cancer.Methods 213 cases of hormone receptor-negative breast cancer were collected,which never receive adjunctive therapy.Using tissue microarray immunohistochemistry methods and flourescence in situ hybridization,according to the expression of HER2 and basal markers,we categorized 213 consecutive hormone receptor-negative invasive breast cancers into 4 subtypes.Expression of p53,p63,vimentin was assessed immunochemically.The clinicopathological features and prognosis of those patients were retrospectively evaluated.Results Four subtypes were classified: Pure-HER2 breast cancers 56(26.3%),Basal-like breast cancers 93(43.7%),Basal-HER2 breast cancers 19(8.9%),null phenotype 45(21.1%).The 3-,5-and 10-year disease-free survival(DFS) was 80.6%,77.5%,74.2% respectively.The corresponding overall survival(OS) rate was 82.7%,79.6%,74.1% respectively.No significant difference was found in 5-year survival among basal-like and the other hormone receptor-negative phenotypes.Basal-like tumors appear to have a relatively good 5-year survival,but survival after metastases is poor.Conclusion Basal-like breast cancers identified by microarray profiling are unusual subtype of invasive breast cancer,with unique immunophenotype,distinctive morphological features,no significant difference was found in 5-year survival among basal-like and the other hormone receptor-negative phenotypes,but survival after node metastases is poor." @default.
- W2377690069 created "2016-06-24" @default.
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- W2377690069 date "2011-01-01" @default.
- W2377690069 modified "2023-09-26" @default.
- W2377690069 title "Clinicopathological characteristics and prognostic significance of the Basal-like subtype of invasive breast carcinoma" @default.
- W2377690069 hasPublicationYear "2011" @default.
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