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- W2377698082 abstract "Objective:To analyze the etiology of 506 cases of anemia and jaundice. Method:On the basis of hemolytic screen tests confirming the existence of hemolysis, system analysis and family survey of hemoglobinopathy, erythrocyte membranopathy, erythrocyte enzymopathy and acquired hemolytic diseases were carried out. Result:Of the 506 cases, cause-confirmed hemolytic diseases were 384 cases, unknown-cause hemolytic diseases 21 cases, nonhemolytic hematologic diseases 33 cases, non-hematologic diseases 24 cases and follow-up-missing 44 cases. In the 384 cause-confirmed hemolytic cases, heredity hemolysis were 356, of whom hemoglobinopathy was 114, membranopathy 133, enzymopathy 65 and compound heterozygote 44 (12.36%). Combining the etiological factors with compound heterozygotes, the total percentage of hemoglobinopathy was 34.62%, membranopathy 42.56% and enzymopathy 22.82%. Of erythrocyte defected enzymes, glucose-6-phosphate dehydrogenase were 41.57%, pyruvate kinase 44.94%, pyrimidine 5'-nucleotidase 3.37%, phosphofructokinase 3.37%, NADH-Diaphorase 4.49%, aldolase 1.12%, glutathione reductase 1.12%. Conclusion:The diagnostic clues of double heterozygote could be interferenced by two kinds of abnormalities in erythrocyte. Hemolytic systemic analysis and family survey may improve the etiologically differential diagnosis of hemolytic anemia especially for enzymopathy and double heterozygote." @default.
- W2377698082 created "2016-06-24" @default.
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- W2377698082 date "2005-01-01" @default.
- W2377698082 modified "2023-09-25" @default.
- W2377698082 title "Compound heterozygote factor and clinical significance of hemolysis system analysis in the diagnosis of congenital hemolytic anemia:Etiological analysis of 506 cases of anemia and jaundice" @default.
- W2377698082 hasPublicationYear "2005" @default.
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