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- W2377700003 abstract "Objective To develop a rat model of periapical periodontitis caused by repeated root canal infection with Enterococcusfaecalis (E.faecalis),and to evaluate the disease progression by observing the periapical lesion area, inflammation,and TNF-αexpression in the root apex.Methods Thirty Sprague Dawley rats were used in this study.The pulps of the bilateral first maxillary molar teeth of each rat were exposed,absorbent cotton with lipopolysaccharides(LPS)was implanted,and then the teeth were exposed in the oral environment for four weeks to induce periapical periodontitis of primary root canal infection with mixed bacteria.Then the root canal was subjected to disinfection treatment for two weeks,followed by inoculation with E.faecalis suspension for one week to produce repeated root canal infection model with E.faecalis for a 3- week observation.X-ray,H-E staining and immunohistochemical staining were used to observe the periapical lesion area, inflammation,and TNF-αexpression in the root apex at one week,two weeks,three weeks after establishment of repeated root canal infection model;the above parameters were also observed for periapical periodontitis caused by primary root canal infection with mixed bacteria(6weeks later)and for root canal disinfected by Ca(OH)2(for 6weeks).Results (1)Periapical periodontitis caused by repeated root canal infection with E.faecalis had gradually increased periapical lesion area,with unclear damage border;the infection reached a severe level during the 1-2weeks and became chronic inflammation at week three;and the expression of TNF-αbegan to decrease after two weeks.(2)The periapical periodontitis caused by primary root canal infection with mixed bacteria had a smaller periapical lesion area,with clear damage border,slighter infiltration of inflammatory cells,and less TNF-αexpression.(3)The periapical periodontitis with root canal disinfected by Ca(OH)2had the smallest periapical lesion area,with disappeared inflammation,slight TNF-αexpression,and hyperplasia of cementum and alveolar bone.Conclusion E.faecalis has a strong periapical damaging effect,with continuous bone absorption observed even under the chronic inflammatory status." @default.
- W2377700003 created "2016-06-24" @default.
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- W2377700003 date "2013-01-01" @default.
- W2377700003 modified "2023-09-23" @default.
- W2377700003 title "Progression analysis of periapical periodontitis caused by repeated root canal infection with Enterococcus faecalis" @default.
- W2377700003 hasPublicationYear "2013" @default.
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