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- W2377702673 abstract "OBJECTIVE To investigate the protected effect and mechanism of Resolvin E1 on hepatic injured mice with schistosomiasis japonica by detecting the expression levels of cytokines and liver coefficient. METHODS 30 Kunming mice were divided randomly into three groups: normal control group, model control group and treated group ( injected RvE1). Mice were infected with schistosoma japonicum cercariae percutaneously, to construct mice models of hepatic injury of schis-tosomiasis japonica. 5 weeks after infection, normal saline was injected in model control group mice by tail vein once a day, and RvE1 was injected in treated group mice by tail vein once a day with 100 ng. The groups were continuously administered to the end of the 10th week after infection. The mice were killed at the end of the 10th week after infection , studied the changes of liver morphology and liver function. Activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were determined by ELISA. The expression levels of TNF-α were detected by RT-PCR and western blotting. RESULTS After 10 weeks of infection, the liver coefficient, serum ALT and AST activities were respectively (84.9 ± 10.3) mg / g, (331.60 ± 49.21) U/L, and (368.74 ± 72.76) U/L in model group, and compared with the model control group, the RvE1 treated group showed effects of restoring liver tissue, reducing the liver coefficient ( 68.6 ± 5.1) , serum ALT (97.82 ± 21.66) U/L and AST (156.19 ± 38.81) U/L activities and there was a significant difference (P﹤0.01). The expression level of TNF-α in RvE1 treated mice was significantly lower than with the model control group. CONCLUSION The results indicate that RvE1 could protect the liver against hepatic injury in mice with schistosomiasis japonica by anti-inflam- matory." @default.
- W2377702673 created "2016-06-24" @default.
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- W2377702673 date "2013-01-01" @default.
- W2377702673 modified "2023-09-24" @default.
- W2377702673 title "Protective effects of Resolvin E1 for hepatic injury in mice with schistosomiasis japonica" @default.
- W2377702673 hasPublicationYear "2013" @default.
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