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- W2377722473 abstract "OBJECTIVE: To investigate the protective effects of Shenfu injection (SFI) on myocardial ischemia-reperfusion injury (MI/RI) model rats. METHODS:MI/RI model was established by opening the chest and ligating the anterior descending branches of the left coronary arteries (LAD) for 30 min, followed by 120 min reperfusion. Model rats were divided into normal control group (constant volume of normal saline), sham operation control group (constant volume of normal saline), model group (constant volume of normal saline) and SFI group(10 mg/kg). The activities of SOD and GSH-PX in the myocardial tissue and the activities of CK and LDH in the serum were all determined. Flow cytometry was employed to assay the expression of apoptosis related genes Bcl-2 and Bax in the blood plasma. RESULTS: Compared with sham operation group, the activities of SOD and GSH-PX were decreased significantly in model group, while the activities of CK and LDH were enhanced significantly; the content of MDA and the expression of Bax were increased significantly while the expression of Bcl-2 was decreased significantly(P001 or P0.05). Compared with model group, the activities of SOD and GSH-PX and the expression of Bcl-2 were increased significantly in SFI group while the activities of CK and LDH, the content of MDA and the expression of Bax were decreased significantly(P0.01 or P0.05). CONCLUSIONS: SFI pretreatment have a protective effect on MI/RI, which might be associated with anti-oxygen free radical, protecting muscular tissues and suppressing myocardial cells apoptosis." @default.
- W2377722473 created "2016-06-24" @default.
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- W2377722473 date "2013-01-01" @default.
- W2377722473 modified "2023-09-26" @default.
- W2377722473 title "Protective Effects of Shenfu Injection Pretreatment on Myocardial Ischemia-reperfusion Injury Model Rats" @default.
- W2377722473 hasPublicationYear "2013" @default.
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