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- W2377729297 abstract "Objective:To study the cell mediated immune repsonses in mice induced by direct plasmid pBK CMV immunization and pave a way for the further research of HCV DNA vaccine Methods:Used recombinant plasmid pBK CMV to transfect a syngeneic SP2/0 myeloma cells and established SP2/0D cell lines which can express HCV structural proteins DNA immunized mice were inoculated with native SP2/0 or SP2/0D cells respectively Activity of T lymphocytes was observed through tumor formation, tumor weight,T lymphocytes infiltration in tumor tissue and the level of IL 2,IFN γ in the serum of all immunized mice Results:Inoculated with SP2/0D or native SP2/0 15 days later, tumor weight in the SP2/0D inoculated mice immnunized with pBK CMV plasmid was remarkably reduced compared with mice immunized with blank plasmid,or inoculated with SP2/0 The level of IL 2 and IFN γ in the serum of pBK CMV immunized groups were higher than those of blank plasmid immunized mice In addition, the phenomena of T lymphocyte infiltration in tumor tissues were very apparent in the SP2/0D inoculated mice immnunized with pBK CMV plasmid Conclusion:The results indicate that recombinant plasmid pBK CMV can induce significant T lymphocytes activity in vivo by this technique, and HCV DNA immunization is a promising approach for vaccine development" @default.
- W2377729297 created "2016-06-24" @default.
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- W2377729297 date "2002-01-01" @default.
- W2377729297 modified "2023-09-25" @default.
- W2377729297 title "DNA immunization of mice with a plasmid encoding hepatitis Cvirus structural proteins elicits significant cell-mediated immune responses" @default.
- W2377729297 hasPublicationYear "2002" @default.
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