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- W2377736199 abstract "Objective To investigate the changes of neuron specific enolase( NSE) in cerebrospinal fluid( CSF) in patients with diffuse axonal injury( DAI),and its relationship with prognosis of DAI. Methods The NSE levels in CSF were detected by radioimmunoassay in 79 patients with DAI( experimental group) and 15 patients without nervous system disease( control group). The CSF samples were collected within 24 hours,and 2-3,7 and 14 days after the patients got head injury. According to the GOS scores,the patients in the experimental group were divided into good prognosis group( n = 41),poor prognosis group( n = 29) and death group( n = 9) three months after they had got head injury. The relationship between the NSE level and prognosis of DAI was analyzed. Results The level of NSE in the experimental group was significantly higher than that in the control group( P 0. 01),the level of NSE in the patients with poor prognosis patients was significantly higher than that in the patients with good prognosis( P 0. 05). the level of NSE in the death group was significantly higher than that in the patients with good prognosis or poor prognosis( P 0. 01).The dynamic observation on NSE showed that the level of NSE in the patients with good prognosis decreased steadily,and was closed to the level of control group on the 7th day after they got head injury. On the 7th day after the patients got head injury,the level of NSE in the patients with poor prognosis was still higher than that in the control group,but wasclosed to the level of control group on the 14th day after they got head injury. Persisting high NSE level was found in the death group. Conclusion Higher levels of NSE in CSF,longer recovery time and poorer prognosis in patients with DAI. The dynamic detection of NSE in CSF can be a reliable index of monitoring and prognosis for patients with DAI." @default.
- W2377736199 created "2016-06-24" @default.
- W2377736199 creator A5061130250 @default.
- W2377736199 date "2014-01-01" @default.
- W2377736199 modified "2023-09-28" @default.
- W2377736199 title "Significance of Neuron-Specific Enolase in Cerebrospinal Fluid in Evaluation of Prognosis of Diffuse Axonal Injury" @default.
- W2377736199 hasPublicationYear "2014" @default.
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